@Reptile71 what version of Windows?
how many USB devices would you say you have… are there any hubs, powered or unpowered, or is everything directly connected
if you check your motherboard manual, it might indicate which USB ports on front/back are powered by various controller-chipsets…
maybe try plugging your critical hotas stuff into a USB port backed by the chipset on the motherboard, vs the CPU … or vice versa
(sry no idea just some random tips to try)